Jadwiga M. Giebultowicz
Emeritus Appointment
Department of Integrative Biology
Jadwiga M. Giebultowicz
Emeritus Appointment
Department of Integrative Biology
Biography
My research is focused on understanding the mechanisms and significance of biological (circadian) clocks, which regulate processes from gene expression to behavior. My projects integrate genetic, biochemical, and physiological experiments with current genomic approaches. Some recent work is listed below, and more can be found on my PubMed page. Please visit my website for more details.
Courses Taught
BI 319 : Critical Thinking and Communications in the Life Sciences
Publications
- Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. Katewa SD, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, Hall D, Davis S, Nelson CS, Brem RB, Ramanathan A, Sehgal A, Giebultowicz JM, Kapahi P. Cell Metab. 2016 Jan 12;23(1):143-54. doi: 10.1016/j.cmet.2015.10.014. Epub 2015 Nov 25.
- Accelerated food source location in aging Drosophila. Egenriether SM, Chow ES, Krauth N, Giebultowicz JM. Aging Cell. 2015 Oct;14(5):916-8. doi: 10.1111/acel.12361. Epub 2015 Jun 23.
- Ageing and Circadian rhythms. Giebultowicz JM, Long DM. Curr Opin Insect Sci. 2015 Feb 1;7:82-86.
- Aging alters circadian regulation of redox in Drosophila. Klichko VI, Chow ES, Kotwica-Rolinska J, Orr WC, Giebultowicz JM, Radyuk SN. Front Genet. 2015 Mar 9;6:83. doi: 10.3389/fgene.2015.00083. eCollection 2015.
- Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila. Blake MR, Holbrook SD, Kotwica-Rolinska J, Chow ES, Kretzschmar D, Giebultowicz JM. Neurobiol Dis. 2015 May;77:117-26. doi: 10.1016/j.nbd.2015.02.012. Epub 2015 Mar 10.
- Relationships between the circadian system and Alzheimer's disease-like symptoms in Drosophila. Long DM, Blake MR, Dutta S, Holbrook SD, Kotwica-Rolinska J, Kretzschmar D, Giebultowicz JM. PLoS One. 2014 Aug 29;9(8):e106068. doi: 10.1371/journal.pone.0106068. eCollection 2014.
- Effects of exercise on circadian rhythms and mobility in aging Drosophila melanogaster. Rakshit K, Wambua R, Giebultowicz TM, Giebultowicz JM. Exp Gerontol. 2013 Nov;48(11):1260-5. doi: 10.1016/j.exger.2013.07.013. Epub 2013 Aug 2.
- Cryptochrome restores dampened circadian rhythms and promotes healthspan in aging Drosophila. Rakshit K, Giebultowicz JM. Aging Cell. 2013 Oct;12(5):752-62. doi: 10.1111/acel.12100. Epub 2013 Jun 25.
- Effects of period RNAi on V-ATPase expression and rhythmic pH changes in the vas deferens of Spodoptera littoralis (Lepidoptera: Noctuidae). Kotwica-Rolinska J, Gvakharia BO, Kedzierska U, Giebultowicz JM, Bebas P. Insect Biochem Mol Biol. 2013 Jun;43(6):522-32. doi: 10.1016/j.ibmb.2013.03.002. Epub 2013 Mar 14.
- Circadian regulation of glutathione levels and biosynthesis in Drosophila melanogaster. Beaver LM, Klichko VI, Chow ES, Kotwica-Rolinska J, Williamson M, Orr WC, Radyuk SN,Giebultowicz JM. PLoS One. 2012;7(11):e50454. doi: 10.1371/journal.pone.0050454. Epub 2012 Nov 30.
- Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. Krishnan N, Rakshit K, Chow ES, Wentzell JS, Kretzschmar D, Giebultowicz JM. Neurobiol Dis. 2012 Mar;45(3):1129-35. doi: 10.1016/j.nbd.2011.12.034. Epub 2011 Dec 27.
- Effects of aging on the molecular circadian oscillations in Drosophila. Rakshit K, Krishnan N, Guzik EM, Pyza E, Giebultowicz JM. Chronobiol Int. 2012 Feb;29(1):5-14. doi: 10.3109/07420528.2011.635237.
